Factors influencing immunogenic and allergenic activity of proteins

Fatima Ferreira

Immunogenicity is defined as the ability of an antigen to induce normal and protective immune responses following contact with the human immune system, whereas allergenicity is specifically viewed as the capacity to induce Th2-polarized responses leading to the production of specific IgE antibodies. In this presentation, the factors determining the immunogenic and allergenic behaviour of antigens will be examined, with a focus on intrinsic and structural characteristics of allergenic proteins. In addition, the possible impact of the allergen source matrix on immune responses to allergens will be explored and discussed.