Microbiome – Linking diet and intestinal barrier function

Mahesh Desai

The human gut microbiome plays key roles in health and disease.

Although diet is a major driver of the microbiota physiology, the gut microbiota-mediated mechanisms that link diet to intestinal disorders, enteric infections and food allergy sensitization are poorly understood.

Our work is focused on discerning these mechanisms and underlying eco-immunological processes via colonic mucus barrier−gut microbiota interactions.

Since the modern diet of developed countries includes significantly reduced dietary fiber, we seek to understand how a fiber-deprived gut microbiota impacts human health.